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首页 > 产品中心 > 重组蛋白 > 激素(Hormone) > Recombinant Exendin-4 Protein

Recombinant Exendin-4 Protein

rExendin-4
TDSSDS
价格:
询价
货号:
1N1901
数量:
-
+
img

技术参数

DESCRIPTION

Expression system

E. coli

Accession number

His48-Ser86, Accession #P26349

Amino acid sequence HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS
Molecular mass

Recombinant Exendin-4 Protein, a monomer containing 39 amino acid residues, has a predicted molecular mass of approximately 4.2 kDa.

SPECIFICATIONS

Purity

> 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin

Less than 0.01 EU/μg of rExendin-4 as determined by LAL test.

Activity

1. Regulates Glucose levels rapidly; 2. Reduces Insulin resistance; 3. Reduces Glucagon; 4. Reduces HbA1c; 5. Stimulates beta cell growth which stimulates insulin production.

Formulation

Lyophilized from a 0.22 μm filtered solution in PBS. See CoA for details.

Reconstitution

Always centrifuge tubes before opening. Do not mix by vortex or pipetting. Reconstitute in sterile distilled water to a concentration of 0.1-1.0 mg/mL. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

SHIPPING & STORAGE

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.

Storage

Please use a manual defrost freezer and avoid repeated freeze-thaw cycles.

  • Lyophilized protein should be stored at ≤ -20°C, stable for 12 months after receipt.
  • Reconstituted protein solution can be stored at 2-8°C for 1 month.
  • Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

BACKGROUND

Exendin‑4 is a 39‑amino‑acid peptide naturally derived from the saliva of the Gila monster (Heloderma suspectum). It is a long‑acting glucagon‑like peptide‑1 (GLP‑1) receptor agonist with high sequence homology to mammalian GLP‑1. Unlike endogenous GLP‑1, Exendin‑4 is resistant to degradation by dipeptidyl peptidase‑4 (DPP‑4), resulting in prolonged biological half‑life. It stimulates insulin secretion, suppresses glucagon release, slows gastric emptying and reduces food intake, making it widely used in research on diabetes mellitus, obesity and metabolic disorders. Recombinant Exendin‑4 is non‑glycosylated, commonly produced in Escherichia coli, and serves as an essential tool protein for GLP‑1 pathway studies and drug screening.

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